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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B1 All Species: 36.06
Human Site: S488 Identified Species: 66.11
UniProt: O75533 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75533 NP_036565.2 1304 145830 S488 D V D E S T L S P E E Q K E R
Chimpanzee Pan troglodytes XP_516006 1379 153963 S563 D V D E S T L S P E E Q K E R
Rhesus Macaque Macaca mulatta XP_001086317 1397 156322 S581 D V D E S T L S P E E Q K E R
Dog Lupus familis XP_857149 1312 146628 S496 D V D E S T L S P E E Q K E R
Cat Felis silvestris
Mouse Mus musculus Q99NB9 1304 145798 S488 D V D E S T L S P E E Q K E R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421912 1383 154834 S567 D V D E S T L S P E E Q K E R
Frog Xenopus laevis O57683 1307 146196 S491 D V D E S T L S P E E Q K E R
Zebra Danio Brachydanio rerio XP_684311 1315 147162 S499 E V D E S T L S P E E Q K E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623732 1315 147662 S499 D V D E E T L S P E E Q K E R
Nematode Worm Caenorhab. elegans NP_497853 1322 147305 K495 D D M Q Y F D K L L M D V D E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002323970 1267 141858 K455 E L S P E E Q K E R K I M K L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201232 1269 141432 E454 N E E E L S P E E Q K E R K I
Baker's Yeast Sacchar. cerevisiae P49955 971 110009 M257 L L I D E D P M V R S T G Q E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 93.3 99.3 N.A. 99.9 N.A. N.A. N.A. 93.7 96.6 93.7 N.A. N.A. 82.4 65.1 N.A.
Protein Similarity: 100 94.5 93.3 99.3 N.A. 100 N.A. N.A. N.A. 93.7 98.3 96.4 N.A. N.A. 88.9 76.6 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. 100 100 93.3 N.A. N.A. 93.3 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. 100 100 100 N.A. N.A. 93.3 20 N.A.
Percent
Protein Identity: 68.4 N.A. N.A. 68.3 40.4 N.A.
Protein Similarity: 79.3 N.A. N.A. 79.1 53.1 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. 60 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 70 8 70 8 0 8 8 0 0 0 0 8 0 8 0 % D
% Glu: 16 8 8 77 24 8 0 8 16 70 70 8 0 70 16 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 8 % I
% Lys: 0 0 0 0 0 0 0 16 0 0 16 0 70 16 0 % K
% Leu: 8 16 0 0 8 0 70 0 8 8 0 0 0 0 8 % L
% Met: 0 0 8 0 0 0 0 8 0 0 8 0 8 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 8 0 0 16 0 70 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 0 8 0 0 8 0 70 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 16 0 0 8 0 70 % R
% Ser: 0 0 8 0 62 8 0 70 0 0 8 0 0 0 0 % S
% Thr: 0 0 0 0 0 70 0 0 0 0 0 8 0 0 0 % T
% Val: 0 70 0 0 0 0 0 0 8 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _